Recent developments of novel matrices and on-tissue chemical derivatization reagents for MALDI-MSI
نویسندگان
چکیده
منابع مشابه
The use of hydrazine-based derivatization reagents for improved sensitivity and detection of carbonyl containing compounds using MALDI-MSI.
Hydrazine-based derivatization reagents have been used to detect the presence of the carbonyl containing glucocorticoid fluticasone proprionate in rat lung tissue by MALDI-MSI. Such reagents also act as a matrix for analysis by MALDI-MS and have been termed "reactive matrices". Cryosections of rat lung tissue (12 μm), spotted with a range of concentrations of fluticasone proprionate, were deriv...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2020
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-020-03023-7